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Effects of co‐administration of dopamine and vitamin C on ischaemia‐reperfusion injury after experimental testicular torsion‐detorsion in rats
Author(s) -
Azizollahi S.,
Babaei H.,
Derakhshanfar A.,
Oloumi M.M.
Publication year - 2011
Publication title -
andrologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.633
H-Index - 59
eISSN - 1439-0272
pISSN - 0303-4569
DOI - 10.1111/j.1439-0272.2009.01028.x
Subject(s) - testicular torsion , dopamine , endocrinology , medicine , ischemia , vitamin c , antioxidant , reperfusion injury , vasodilation , vitamin e , vitamin , chemistry , surgery , biochemistry
Summary The objective of this study was to investigate the effects of dopamine as vasodilator, vitamin C as an antioxidant and combined administration of them on ischaemia‐reperfusion (I‐R) injury following testicular torsion (TT). Thirty adult male rats were divided into six groups each containing five rats. Testicular ischaemia was achieved by twisting the left testis for 4 h. Group 1 was for determination of the basal values. Group 2 had 4 h TT. Group 3 had 4 h TT and was then treated with dopamine. Group 4 had 4 h TT and was then treated with vitamin C. Group 5 had 4 h TT and was then treated with dopamine and vitamin C. Group 6 was designed as a sham operated group. Testicular torsion caused a significant decrease in the percentage of spermatogenesis and seminiferous tubules diameters compared with the control and sham groups. Administration of dopamine, vitamin C and their combination increased above mentioned parameters and decreased serum malondialehyde levels significantly. However, vitamin C had better results than the other treatments ( P < 0.05). In conclusion, a potent antioxidant like vitamin C was found to be more effective than increasing blood flow by a vasodilator like dopamine on improving I‐R injury following TT.