Premium
Role of glutathione S‐transferase Mu‐1 (GSTM1) polymorphism in oligospermic infertile males
Author(s) -
Tirumala Vani G.,
Mukesh N.,
Siva Prasad B.,
Rama Devi P.,
Hema Prasad M.,
Usha Rani P.,
Pardhanandana Reddy P.
Publication year - 2010
Publication title -
andrologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.633
H-Index - 59
eISSN - 1439-0272
pISSN - 0303-4569
DOI - 10.1111/j.1439-0272.2009.00971.x
Subject(s) - genotype , male infertility , glutathione s transferase , infertility , sperm motility , biology , sperm , glutathione , oligospermia , medicine , andrology , polymorphism (computer science) , endocrinology , gynecology , genetics , gene , enzyme , pregnancy , biochemistry
Summary The aim of this study was to examine whether an association exists between glutathione S‐transferase Mu‐1 ( GSTM1 ) gene polymorphism and idiopathic male infertility. Forty‐two men with infertility and 43 fertile men were recruited for this study. GSTM1 gene was analysed using PCR technique. The frequency of GSTM1 null (−) genotype was observed to be 45.2% in infertile men as against 20.09% in fertile men. Subjects with the GSTM1 null genotype had lower sperm concentrations and motility when compared with the subjects with GSTM1 ‐positive genotype in both the groups. This study shows that the frequency of GSTM1 null (−) genotype is significantly high in infertile males when compared with the frequency in fertile males (OR = 0.32, P = 0.017, 95% CI = 0.124–0.831).