Premium
Seminal reactive oxygen species‐antioxidant relationship in fertile males with and without varicocele
Author(s) -
Mostafa T.,
Anis T.,
Imam H.,
ElNashar A. R.,
Osman I. A.
Publication year - 2009
Publication title -
andrologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.633
H-Index - 59
eISSN - 1439-0272
pISSN - 0303-4569
DOI - 10.1111/j.1439-0272.2008.00900.x
Subject(s) - varicocele , malondialdehyde , sperm , andrology , reactive oxygen species , male infertility , oxidative stress , superoxide dismutase , sperm motility , glutathione peroxidase , infertility , catalase , medicine , endocrinology , biology , biochemistry , pregnancy , genetics
Summary The aim of this study was to assess seminal reactive oxygen species (ROS)‐antioxidants relationship in fertile and infertile men with and without varicocele. One hundred and seventy six males were studied; fertile healthy volunteers ( n = 45), fertile men with varicocele ( n = 45), infertile oligoasthenozoospermia (OA, n = 44) without varicocele and infertile OA with varicocele ( n = 42). In their seminal plasma, two ROS parameters (malondialdehyde, hydrogen peroxide) and five antioxidants (superoxide dismutase, catalase, glutathione peroxidase, vitaminE, vitaminC) were estimated. Compared with fertile healthy men, in all other studied groups, estimated seminal ROS were significantly higher and estimated antioxidants were significantly lower. Infertile men with varicocele showed the same relationship as infertile men without varicocele. Sperm concentration, total sperm motility as well as sperm normal forms were negatively correlated with seminal malondialdehyde and were positively correlated with vitaminC . It is concluded that varicocele has an oxidative stress (OS) in fertile normozoospermic bearing conditions. This may allow understanding that, within men with varicocele, there is a threshold value of OS over which male fertility may be impaired.