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Oestrogens and Crohn’s disease: the missed link
Author(s) -
ElTawil A. M.
Publication year - 2008
Publication title -
andrologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.633
H-Index - 59
eISSN - 1439-0272
pISSN - 0303-4569
DOI - 10.1111/j.1439-0272.2008.00836.x
Subject(s) - crohn's disease , disease , observational study , hormone , medicine , inclusion (mineral) , crohn disease , physiology , bioinformatics , biology , psychology , social psychology
Summary Observational studies, sometimes, can not provide us with clear answers for very important questions. The answer for a question on whether sex hormones in general, and oestrogen in particular, play some role in inducing and development of Crohn’s disease is uncertain. Study design, inclusion criteria, and different formulations of oral contraceptives may partly explain the conflict results of the published reports. But these may be due to the divergent effects of oestrogen, which are based on dose, tissue specificity and cellular environment. This paper is aimed at examining the influence of androgens on the prognosis of Crohn’s disease.