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Tadalafil as an in vitro sperm motility stimulant
Author(s) -
Mostafa T.
Publication year - 2007
Publication title -
andrologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.633
H-Index - 59
eISSN - 1439-0272
pISSN - 0303-4569
DOI - 10.1111/j.1439-0272.2006.00752.x
Subject(s) - tadalafil , sperm , motility , sperm motility , andrology , semen , in vitro , chemistry , erectile dysfunction , biology , medicine , biochemistry , microbiology and biotechnology
Summary Tadalafil (Cialis ® ) is a known oral selective phosphodiesterase‐5 inhibitor used widely in the management of erectile dysfunction. To assess its ability on human sperm motility in vitro , 70 asthenozoospermic semen specimens delivered by masturbation were investigated. Semen samples were divided equally into four tubes, one as a control and to the others tadalafil dissolved solution was added in vitro in three different concentrations (4.0, 1.0, 0.5 mg ml −1 respectively). The tubes were incubated and were followed up for sperm motility per cent changes for 0.5, 1, 2, 3 h. It was found that the concentration used played an important role in the degree of sperm enhancement. Specimens treated with 4 mg ml −1 tadalafil solution demonstrated a significant decrease in sperm motility compared with the controls. Specimens treated with 1.0 mg ml −1 solution demonstrated significant increase in sperm progressive forward motility. Specimens treated with 0.5 mg ml −1 solution demonstrated significant increases in sperm motility but lower than that of 1 mg ml −1 concentration. It is concluded that in vitro use of tadalafil solution in special concentration has a significant stimulatory effect on asthenozoospermic sperm motility.