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Impairment of human sperm motility and viability by quercetin is independent of lipid peroxidation
Author(s) -
Khanduja K. L.,
Verma A.,
Bhardwaj A.
Publication year - 2001
Publication title -
andrologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.633
H-Index - 59
eISSN - 1439-0272
pISSN - 0303-4569
DOI - 10.1111/j.1439-0272.2001.tb01496.x
Subject(s) - lipid peroxidation , sperm , quercetin , motility , sperm motility , andrology , chemistry , viability assay , biology , biochemistry , antioxidant , in vitro , medicine , microbiology and biotechnology
Summary Human sperm motility, viability and lipid peroxidation were assessed in Ringer‐Tyrode supplemented with different concentrations of quercetin. An irreversible and dose‐dependent fall in sperm motility was observed with quercetin (5–200 μM). However, sperm viability was decreased only at higher concentrations (50–100 μM) of quercetin. This inhibition in sperm motility and viability has been linked with decreased Ca 2+ ‐ATPase activity, as there was no effect of quercetin on sperm lipid peroxidation.