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New aspects in Peyronie's disease—a mini‐review
Author(s) -
SchroederPrintzen I.,
Hauck E. W.,
Weidner W.
Publication year - 1999
Publication title -
andrologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.633
H-Index - 59
eISSN - 1439-0272
pISSN - 0303-4569
DOI - 10.1111/j.1439-0272.1999.tb01448.x
Subject(s) - peyronie's disease , medicine , pathogenesis , tamoxifen , magnetic resonance imaging , disease , surgery , radiology , pathology , cancer , breast cancer
Summary. There have been several advances in elucidation of the pathogenesis of Peyronie's disease. Transforming growth factor β1 seems to play a major role in this disease, while the importance of penile trauma is a matter of debate. High‐resolution ultrasound sonography is the method of choice in detecting penile plaques, while magnetic resonance imaging is useful in the evaluation of actively inflamed plaques. There are still differences of opinion on the best drug therapy in noncalcified plaques. The results on tamoxifen or interferon therapy vary between useless and useful. Potassium‐para‐aminobenzoate seems to have a significant effect in decreasing plaque size and deviation angle. The operative strategy for big plaques or complex deviation has changed to the ‘small incision’ graft, leading to far lower postoperative impotence rates. Iontophoresis seems to be worthy of further trials, while the results of extracorporal shock wave therapy have to be discussed critically.