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Effects of short‐term high‐dose testosterone propionate administration on medium molecular‐weight proteins of human seminal plasma
Author(s) -
Carpino A.,
Sisci D.,
Aquila S.,
Beraldi E.,
Sessa M. T.,
Siciliano L.,
Luca G.,
Andò S.
Publication year - 1994
Publication title -
andrologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.633
H-Index - 59
eISSN - 1439-0272
pISSN - 0303-4569
DOI - 10.1111/j.1439-0272.1994.tb00795.x
Subject(s) - endocrinology , medicine , testosterone propionate , testosterone (patch) , lactoferrin , fructose , androgen , prostate , acid phosphatase , hormone , chemistry , albumin , biochemistry , enzyme , cancer
Summary. Effects of short‐term high‐dose testosterone propionate treatment on medium molecular‐weight proteins (lactoferrin, albumin, prostatic acid phosphatase, prostate specific antigen) and on zinc and fructose levels were investigated in the seminal plasma of seven normal volunteers. A significant reduction in levels of prostatic‐acid phosphatase, zinc and, to a lesser degree, prostate‐specific antigen, lactoferrin and fructose was observed on the 14th day of androgen treatment, concomitantly with the maximal increase in free androgen‐circulating levels. The data obtained suggest that testosterone administration may induce a reduction in the sex accessory‐gland secretion. Indeed, this effect tends to disappear with withdrawal of hormone treatment. Therefore, the authors suggest a close follow‐up of prostatic and vesicular function during the long‐term high‐dose testosterone intake, used frequently as anabolic treatment by athletes and body builders.