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Ghloroquine excretion in semen following antimalarial‐drug administration
Author(s) -
Adeeko A. O.,
Dada O.A.
Publication year - 2009
Publication title -
andrologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.633
H-Index - 59
eISSN - 1439-0272
pISSN - 0303-4569
DOI - 10.1111/j.1439-0272.1994.tb00782.x
Subject(s) - chloroquine , semen , drug , pharmacology , excretion , medicine , chemotherapy , malaria , andrology , immunology
Summary. The study described here was carried out to establish whether or not chloroquine was excreted in semen. Chloroquine was assayed in the semen of eight male volunteers (aged between 19 and 45 years) by a fluorimetric method before and after taking a total dose of 1.500 mg chloroquine base corresponding to the accepted dosage of the drug in malarial chemotherapy. Mean pre‐and post‐drug administration levels of 0.7 ± 0.2 μM and 5.7 ± 0.6 μM were obtained respectively, indicating a significant excretion of chloroquine in semen.