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Evaluation of spermatozoa of the rat in hyperprolactinaemia induced by Metoclopramide
Author(s) -
Laszczyńska M.,
Rózewicka L.,
Kuchnio M.,
Piasecka M.,
Marchlewicz M.
Publication year - 2009
Publication title -
andrologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.633
H-Index - 59
eISSN - 1439-0272
pISSN - 0303-4569
DOI - 10.1111/j.1439-0272.1992.tb02618.x
Subject(s) - lumen (anatomy) , metoclopramide , duct (anatomy) , epididymis , andrology , medicine , hyperprolactinaemia , endocrinology , chemistry , anatomy , sperm , hormone , prolactin , vomiting
Summary. Metoclopramide (MCP) in doses of 2.2 mg kg −1 body weight, being administered intraperitoneally to rats for 14 d, provokes a premature release of germ cells in the testes. The number of spermatozoa is reduced. In addition the spermatozoa exhibit defects of head and tail structures. After the administration of MCP for 14 d, followed by a 14‐d break in applying the drug, the number of spermatozoa in the lumen of the epididymal duct continues to be low. Many spermatozoa are damaged. Only after a 66‐d‐break in MCP administration is the morphology of the seminiferous epithelium restored, and a large number of spermatozoa appear in the lumen of the epididymal duct.