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Hyperprolactinaemia and hyperserotoninaemia: their relationship to seminal quality
Author(s) -
Gonzales G. F.,
GarciaHjarles M.,
Velasquez G.
Publication year - 2009
Publication title -
andrologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.633
H-Index - 59
eISSN - 1439-0272
pISSN - 0303-4569
DOI - 10.1111/j.1439-0272.1992.tb02617.x
Subject(s) - hyperprolactinaemia , medicine , biology , psychology , gynecology , prolactin , hormone
Summary. Seminal quality and levels of blood serotonin (5‐HT) and serum prolactin (PRL) were determined in 60 men attending an infertility service. Subjects were grouped according to normal or abnormal accessory sex gland function. Subjects with normal accessory sex gland function were further subdivided into groups with asthenozoospermia, polyzoospermia, normozoospermia, oligozoospermia, or azoospermia. Blood 5‐HT levels were significantly higher in oligozoospermics (115.9 ± 23.7 ng ml −1 , P <0.05), and asthenozoospermics (90.0 ± 8.2 ng ml −1 , P <0.05), than in normals (68.5 ± 5.3 ng ml −1 ), whereas serum PRL levels were higher in azoospermics (44.2 ± 4.7 ng ml −1 ) than in normozoospermics (15.9 ± 1.6 ng ml −1 , P <0.01). Subjects with abnormal accessory sex gland function were also subdivided according sperm count and sperm motility categories. None of these subgroups showed differences in serum PRL levels or blood 5‐HT levels. Men with hyperserotoninaemia had higher serum PRL levels, low sperm count, and low motile sperm concentration. Moreover, higher 5‐HT levels may be observed in men with normal PRL levels and also associated with normal PRL levels and with hyperprolactinaemia, and hyperprolactinaemia may be observed also associated with normal serotonin levels. Hyperserotoninaemia was related to both diminished sperm count and sperm motility, whereas hyperprolactinaemia was related to low sperm count. When hyperprolactinaemia and hyperserotoninaemia were both present, additive effects were observed.