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Superoxide radical level and superoxide dismutase activity changes in maturing mammalian spermatozoa
Author(s) -
Pradeep Kumar G.,
Laloraya Malini,
Laloraya Manmohan M.
Publication year - 2009
Publication title -
andrologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.633
H-Index - 59
eISSN - 1439-0272
pISSN - 0303-4569
DOI - 10.1111/j.1439-0272.1991.tb02528.x
Subject(s) - superoxide , superoxide dismutase , chemistry , sperm , reactive oxygen species , oxidative phosphorylation , oxygen toxicity , superoxide radical , radical , biochemistry , oxidative stress , andrology , oxygen , enzyme , medicine , organic chemistry
Summary. Mammalian spermatozoa, which like other living cells are susceptible to oxygen toxicity, generate increasing quantities of superoxide radical as epididymal maturation proceeds. This is associated with a concomitant reduction in the activity of superoxide dismutase. A possible involvement of superoxide radicals in bringing about some of the reported oxidative changes occuring during epididymal maturation of mammalian spermatozoa is discussed. It is suggested that superoxide radical may be involved in regulating membrane changes accompanying sperm maturation.