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Diminution of ejaculatory capacity induced by frequent ejaculation in dogs: Prevention and reversal by yohimbine
Author(s) -
Yonezawa A.,
Kawamura S.,
Ando R.,
Tadano T.,
Nobunaga T.,
Kimura Y.
Publication year - 2009
Publication title -
andrologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.633
H-Index - 59
eISSN - 1439-0272
pISSN - 0303-4569
DOI - 10.1111/j.1439-0272.1991.tb02503.x
Subject(s) - yohimbine , ejaculation , stimulation , medicine , endocrinology , antagonist , receptor
Summary. The effect of yohimbine, an alpha‐2 adrenoceptor antagonist, on diminished ejaculatory capacity induced by frequent ejaculation was investigated in dogs. Ejaculation was elicited by manual penile stimulation (for 5 min) 5–8 times every 30 min. The amount of ejaculate produced by the stimulation was drastically reduced during a period of frequent ejaculation in a frequency‐dependent manner. When administered immediately after the first ejaculation, yohimbine (0.1 mg kg −1 , i.p.) completely prevented the decrease in the amount of ejaculate produced in the succeeding ejaculation. Moreover, similar treatment with yohimbine immediately after the fifth ejaculation when the dogs displayed a greatly reduced ejaculatory capacity restored the capacity to the initial level. In addition, yohimbine increased the total number of sperm produced during a period of frequent ejaculation. These data corroborate our previous finding that yohimbine at a low dose has a stimulatory effect on ejaculatory function in dogs. The present study also indicates that an alpha‐2 adrenergic mechanism may be involved in the diminution of ejaculatory capacity induced by frequent ejaculation.