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Concentration of Calcitonin in Seminal Plasma of Infertile Men/Calcitonin‐Konzentration im Spermaplasma von unfruchtbaren Männern
Author(s) -
Badr O.,
Imam A.,
Monieb H.,
Khalifa A.,
Ahmady O. Al,
Abdallah M. A.
Publication year - 2009
Publication title -
andrologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.633
H-Index - 59
eISSN - 1439-0272
pISSN - 0303-4569
DOI - 10.1111/j.1439-0272.1989.tb02435.x
Subject(s) - calcitonin , endocrinology , medicine , radioimmunoassay , motility , chemistry , calcium , semen , sperm motility , andrology , biology , genetics
Summary: Calcitonin levels in peripheral plasma (8 cases) and seminal fluid (30 cases) were measured by direct Radioimmunoassay (RIA). Their relationship with seminal characteristics, calcium and swelling test were evaluated. Seminal plasma calcitonin averaged 7530 pg/ml which amounts to 142 times higher than that of serum averaging 53 pg/ml. There was no significant difference in the mean seminal plasma concentration of immunoreactive calcitonin (iCT) among normozoospermic, Oligozoospermie and azoospermic groups. However, there was a significant difference (p < 0.05) in the seminal plasma mean concentration between high and low motility groups. A significant correlation was found between iCT seminal plasma concentration and percent of motility (p < 0.05), yet, no correlation was detected between iCT and other seminal characteristics including swelling test (p > 0.05). Seminal plasma calcium averaged 175.3 ± 29.9 mg/L which was 1.75 times higher than that of the serum averaging 100.32 ± 5 mg/L. No significant difference (p < 0.05) was obtained between high and low motility groups as regard their calcium seminal plasma levels. A significant correlation was found between seminal plasma concentration of calcium and calcitonin (p < 0.05), but not with the percent of motility (p < 0.05). Calcitonin (CT) was present in seminal plasma in higher concentrations than those of serum, indicating its active secretion within the male accessory sex glands. The role of CT in human reproduction needs further elucidation, especially regarding sperm motility. Zusammenfassung: In einer experimentellen Arbeit wird über die Calcitonin‐Werte im peripheren Plasma (8 Fälle) und in der Samenflüssigkeit (30 Fälle) berichtet, die mittels direktem Radioimmunoassay (RIA) bestimmt wurden. Es wurden die Beziehungen zwischen den Spermacharakteristika, Calcium und dem Schwell‐Test ausgewertet. Es ergibt sich, daß die Spermaplasma‐Calcitonin‐Werte etwa 142mal höher liegen als die Werte im Serum (53 pg/ml.) Es konnte keine signifikante Differenz in den Mittelwerten der Seminal‐Plasma‐Konzentration von immunreaktivem Calcitonin bei Normozoospermie, Oligozoospermie und Azoospermie festgestellt werden. Nichtsdestoweniger ergab sich eine signifikante Differenz (p < 0,05) zwischen hoher und niedriger Motilität der Spermatozoon im Hinblick auf die Seminal‐Plasma‐Konzentration. Zwischen dem immunreaktiven Calcitonin im Semiplasma und der Motilität ergab sich eine signifikante Korrelation (p < 0,05), dagegen keinerlei Korrelation zwischen dem immunreaktiven Calcitonin und anderen Samencharakteristika einschließlich des Schwelltests.