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Normal Development of the Muscular Region of the Interventricular Septum. II. The Importance of Myocardial Proliferation
Author(s) -
ContrerasRamos A.,
SánchezGómez C.,
FierroPastrana R.,
GonzálezMárquez H.,
AcostaVazquez F.,
ArellanoGalindo J.
Publication year - 2009
Publication title -
anatomia, histologia, embryologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.34
H-Index - 35
eISSN - 1439-0264
pISSN - 0340-2096
DOI - 10.1111/j.1439-0264.2008.00926.x
Subject(s) - interventricular septum , morphogenesis , anatomy , medicine , confocal , cardiology , biology , physics , biochemistry , ventricle , optics , gene
Summary In a first paper, we concluded that the muscular region of the interventricular septum is developed by the trabecular branches and showed evidence that the developing interventricular septum elongates in a direction opposite to that of atria. Nevertheless, to date the literature is lacking precise information on the importance of myocardial proliferation not only in this process but also in the morphogenesis of the ventricular cavities. The aim of this study was to determine the spatial and temporal distribution of high‐intensity foci of cycling myocytes in the ventricular region of the heart of chicken embryos during cardiac septation. Histological studies, detection of the proliferating cell nuclear antigen by light and confocal microscopy and flow cytometric analysis were carried out. The results corroborate that the developing interventricular septum grows in a direction opposite to that of atria. A remoulding mechanism that results in fenestrated trabecular sheets and trabecular branching is discussed. Our findings allowed us to summarize the normal morphogenesis of the muscular region of the interventricular septum in a way that is different from that suggested by other researchers.