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Projections From the Anterior Interposed Nucleus to the Red Nucleus Diminish With Age in the Mouse
Author(s) -
OlynthoTokunaga H. H. V.,
Pinto M. L.,
Souccar C.,
Schoorlemmer G. H. M.,
Lapa R. C. R. S.
Publication year - 2008
Publication title -
anatomia, histologia, embryologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.34
H-Index - 35
eISSN - 1439-0264
pISSN - 0340-2096
DOI - 10.1111/j.1439-0264.2008.00877.x
Subject(s) - nucleus , red nucleus , anatomy , ageing , chemistry , biology , neuroscience , medicine
Summary To analyse the effect of ageing on the projection of the anterior interposed nucleus to the red nucleus, we injected the retrograde tracer fluorogold in the red nucleus of 3‐, 6‐ and 12‐month‐old mice. The number of labelled neurones in the anterior interposed nucleus fell by 9% between 3 and 6 months and by another 9% between 6 and 12 months (all P < 0.001). This suggests that loss of neurones from the cerebellar nuclei starts well before old age.