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Teratogenic Effects of the Interaction Acetylsalicylic Acid (ASA) and Ethanol: Morphologic and Morphometric Evaluation of the Lingual Epithelium in Rat Fetuses
Author(s) -
Marinho S. A.,
Sala M. A.,
Lopes R. A.,
De Moraes Grisi M. F.,
Novaes A. B.,
De Souza S. L. S.,
Taba M.
Publication year - 2007
Publication title -
anatomia, histologia, embryologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.34
H-Index - 35
eISSN - 1439-0264
pISSN - 0340-2096
DOI - 10.1111/j.1439-0264.2006.00712.x
Subject(s) - epithelium , ethanol , fetus , tongue , saline , intraperitoneal injection , anatomy , pathology , medicine , pregnancy , biology , chemistry , biochemistry , genetics
Summary The objective of the present work was to evaluate the teratogenic effects of the interaction between acetylsalicylic acid (ASA) and ethanol on the epithelium of the lingual mucosa in rat fetuses. On the 10th pregnancy day, a single intraperitoneal ethanol dose (2.96 g/kg body weight) (Group I), ASA (200 mg/kg body weight) (Group II) and ASA plus ethanol, in the same doses (Group III), or saline (Group IV – control), were administrated. The epithelial alterations were assessed by means of histological and morphometric methods, on posterior dorsal, anterior dorsal and ventral regions of the tongue. ASA reduced, in rat fetuses, the ethanol deleterious effects on nuclear size in the epithelial prickle cell of the lingual mucosa. On the other hand, ASA did not influence the effects of ethanol in both epithelial layers of the lingual mucosa, when the nuclear shape, cell volume or epithelial layers thickness were evaluated.