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The Neonatal Treatment of Rats with Monosodium Glutamate Induces Morphological Changes in the Subfornical Organ
Author(s) -
Pesini P.,
Rois J. L.,
Menéndez L.,
Vidal S.
Publication year - 2004
Publication title -
anatomia, histologia, embryologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.34
H-Index - 35
eISSN - 1439-0264
pISSN - 0340-2096
DOI - 10.1111/j.1439-0264.2004.00547.x
Subject(s) - subfornical organ , monosodium glutamate , endocrinology , medicine , nitric oxide , central nervous system , glutamate receptor , nitric oxide synthase , ventricle , blood pressure , renin–angiotensin system , receptor
Summary The parenteral administration of monosodium glutamate (MSG) to neonatal rats induces specific lesions in the central nervous system that lead to a well characterized neuroendocrinological dysfunction. Additionally, it has been shown that MSG‐treated rats present a blunted blood pressure response to the injection of nitric oxide synthase inhibitors. Recently, a similar cardiovascular alteration has been reported after the electrolytic lesion of the anteroventral region of the third ventricle affecting the connections of the subfornical organ (SFO). We hypothesized that the treatment of neonatal rats with MSG could affect the nitrergic cells of the SFO. In the present work, we have looked for alterations in the NADPH‐diaphorase activity (a commonly used marker for nitrergic neurons) in the SFO of MSG‐treated rats of either sex and at two different ages. Our results shown that the treatment of neonatal rats with MSG induced a substantial reduction in the volume of the SFO and in the number of its nitrergic cells with regard to control animals. These findings suggest that the SFO could be implicated in some of the cardiovascular alterations observed in MSG‐treated rats.