Premium
Adrenal Renin is Localized in Lysosomal Granules
Author(s) -
Kon Y.,
Hashimoto Y.,
Sugimura M.,
Murakami K.
Publication year - 1993
Publication title -
anatomia, histologia, embryologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.34
H-Index - 35
eISSN - 1439-0264
pISSN - 0340-2096
DOI - 10.1111/j.1439-0264.1993.tb00227.x
Subject(s) - renin–angiotensin system , cathepsin , gestation , cathepsin b , cathepsin d , homogeneous , medicine , endocrinology , chemistry , biology , enzyme , biochemistry , pregnancy , genetics , physics , blood pressure , thermodynamics
Summary Both renin and cathepsin B were co‐localized in identical granules of adrenocortical cells. At day 16 of gestation, many renin‐containing granules were observed and gold particles showed homogeneous intragranular distribution; whereas, those for cathepsin B was distributed heterogene‐ously. At day 18 of gestation, renin immunoreactivity was decreased or undetectable, whereas cathepsin B was still demonstrated at the same level as on day 16 of gestation.