über lysosomale Strukturen im Darmepithel des Säugers während seiner prä‐ und postnatalen Entwicklung. Eine mikromorphologisch‐funktionelle Synopse *

Summary Lysosornes in the mammalian intestinal épithélium during pre‐ and postnatal development The first lysosomes appear in the stratified embiyonic intestinal épithélium during its transition into the simple columnar form. This occurs concurrently with the initial villogenesis. Lysosornes situated basally in the épithélium are presumably the precursor of the first giant lysosornes in the lower small intestine of rodents. Immediately after establishment of the simple configuration a special form of secondary lysosornes can be observed, i. e. glycogenosomes , in the ephemerally existing huge glycogen containing areas. During subsequent fetal intestinal development one observes two events in the epithelial cells, which are the same in principle but differ in one essential point, while they exhibit partially impressive structures. On the one hand there are autophagic degenerative lysosomal processes in the villous épithélium until birth, that lead to a surface without villi in the large intestine, where they occur particularly frequently. On the other hand giant lysosornes originate perinatally in the lower small intestine as well as in the caecum and colon ascendens, in which protein molecules, which were transported by a system of inframicrovillar membranes, are lysosomally degraded, which can be defined as a heterophagic event.