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Die Heterogenität des vaskulären Endothels *
Author(s) -
Plendl Johanna,
Sinowatz Fred,
Auerbach Robert
Publication year - 1992
Publication title -
anatomia, histologia, embryologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.34
H-Index - 35
eISSN - 1439-0264
pISSN - 0340-2096
DOI - 10.1111/j.1439-0264.1992.tb00458.x
Subject(s) - endothelium , immune system , cell adhesion molecule , endothelial stem cell , medicine , microbiology and biotechnology , adhesion , receptor , cell adhesion , immunology , biology , cell , in vitro , chemistry , biochemistry , endocrinology , organic chemistry
Summary Heterogeneity of the vascular endothelium The vascular endothelium has long been considered to be a homogeneous cell type. It is only recently that its remarkable heterogeneity has been shown. The selective and organ‐specific adhesion of cells of the immune system, of metastasizing tumor cells and of microorganisms underscores the central position of the endothelium between the circulation and each organ. The use of antibodies and lectins led to the recognition of species‐, organ‐, and age‐specific endothelial cell surface receptors. Identification of the endothelial adhesion molecules and ‐mechanisms, which are part of the “endothelial organ‐ and tissue address” would lead to the possibility of blocking the adhesion of cells, such as e. g. tumor cells.