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Induction of Thyroid Proliferative Changes in Rats Treated with Antithyroid Compound
Author(s) -
Rodriguez A. Fernandez,
Davidson H. Galera,
Villadiego M. Salguero,
Fernandez A. Moreno,
Lacave I. Martin,
Sanz J. Fernandez
Publication year - 1991
Publication title -
anatomia, histologia, embryologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.34
H-Index - 35
eISSN - 1439-0264
pISSN - 0340-2096
DOI - 10.1111/j.1439-0264.1991.tb00304.x
Subject(s) - vascularity , hyperplasia , thyroid , medicine , endocrinology , muscle hypertrophy , follicular cell , antithyroid drugs , thyroid nodules , homogeneous , pathology , graves' disease , physics , thermodynamics
Summary This study was designed to investigate the histologic changes in goitrogen‐induced thyroid growth of the rat. The animals were orally treated by 1 % potassium perchlorate except the controls and were sacrificed in intervals ranging from 1 to 12 months. The thyroid weight increased progressively along the treatment and after 2 months showed a diffuse homogeneous hypertrophy and hyperplasia of follicular cells, decreased amount of colloid and increased vascularity. After sixth month of treatment true nodules appeared with complex morphology.