Premium
Signaling Pathways in Bacterial Chemotaxis
Author(s) -
Taylor B. L.,
Johnson M. S.,
Smith J. M.
Publication year - 1988
Publication title -
botanica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.871
H-Index - 87
eISSN - 1438-8677
pISSN - 0932-8629
DOI - 10.1111/j.1438-8677.1988.tb00018.x
Subject(s) - chemotaxis , methylation , signal transduction , biology , microbiology and biotechnology , transduction (biophysics) , biochemistry , receptor , gene
The sensory transduction pathways between the transducing proteins and the switch on the flagellar motors have been investigated in Escherichia coli and Salmonella typhimurium . ATP, not GTP, is required for normal chemotaxis. A site of ATP action appears to be the conversion of an inactive form of the CheY protein to an active form, designated CheY*, that binds to the motor switch and initiates clockwise rotation. The methylation‐dependent and methylation‐independent pathways for chemotaxis have a common requirement for the CheA, CheW, and CheY proteins in addition to the switch and flagellar motor. It is concluded that the receptor/transducing proteins and the adaptation mechanism differ in the two types of pathway, but that other components of the transduction pathway are common to the methylation‐dependent and methylation‐independent pathways.