Open AccessThe negative impact of female donor/male recipient combination in allogeneic hematopoietic stem cell transplantation depends on disease risk
Author(s) -
Nannya Yasuhito,
Kataoka Keisuke,
Hangaishi Akira,
Imai Yoichi,
Takahashi Tsuyoshi,
Kurokawa Mineo
Publication year - 2011
Publication title -
transplant international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.998
H-Index - 82
eISSN - 1432-2277
pISSN - 0934-0874
DOI - 10.1111/j.1432-2277.2011.01229.x
Subject(s) - medicine , hematopoietic stem cell transplantation , transplantation , disease , population , stem cell , graft versus host disease , oncology , haematopoiesis , immunology , genetics , biology , environmental health
Summary Optimal donor selection is one of the key factors to enhance the success rate of allogeneic hematopoietic stem cell transplantation (HSCT). The effect of sex mismatch, especially the effect of Y chromosome mismatch in graft‐versus‐host disease (GVHD) direction (female donors to male recipients: denoted as FtoM mismatch) on overall survival (OS) has been controversial and not examined out of the patient population in Western countries. We retrospectively analyzed 225 cases of allogeneic HSCT and showed that FtoM mismatch confers a highly significant impact on OS ( P < 0.005) in Japanese population. We demonstrated that this effect depends on the disease risk; for standard risk cases, this effect was significantly associated with poor outcome (for OS, P = 0.021), while for high risk cases, it had no effect on the results (for OS, P = 0.26). We further showed that FtoM mismatch was associated with nonrelapse mortality ( P = 0.019) and most of them were GVHD‐related in standard risk cases. In conclusion, FtoM mismatch has a significant impact on transplant outcome, especially in standard risk cases.