Open AccessTreatment for BK virus: incidence, risk factors and outcomes for kidney transplant recipients in the United States
Author(s) -
Schold Jesse D.,
Rehman Shezhad,
Kayler Liise K.,
Magliocca Joseph,
Srinivas Titte R.,
MeierKriesche HerwigUlf
Publication year - 2009
Publication title -
transplant international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.998
H-Index - 82
eISSN - 1432-2277
pISSN - 0934-0874
DOI - 10.1111/j.1432-2277.2009.00842.x
Subject(s) - medicine , incidence (geometry) , immunosuppression , bk virus , thymoglobulin , tacrolimus , kidney transplantation , transplantation , intensive care medicine , physics , optics
Summary There has been a notable rise of BK virus among kidney transplant recipients. Single‐center reports have identified risk factors for development of BK virus. However, there has not been an assessment of risk factors and incidence of this complication at a national level. This study utilized newly collected follow‐up information from the national SRTR database to investigate incidence, risk factors and outcomes for solitary kidney transplant recipients associated with treatment for BK virus (TBKV) from 2004 to 2006. Logistic and Cox models were utilized to assess risk factors and evaluate graft survival associated with TBKV. Incidence of TBKV was 1.6% at 6 months and 2.6% at 1 year following transplantation. Patients with and without TBKV at 6 months had 79% and 90% 3‐year overall graft survival respectively. Risk factors included advanced donor age, pediatric, African American and male recipients, human leukocyte antigen‐mismatching and tacrolimus and thymoglobulin induction as baseline immunosuppression. Acute rejection episodes were more frequent prior to and following TBKV. TBKV is a common and rising incidence, varies based on transplant characteristics and should be included as a safety endpoint in studies investigating immunosuppressive protocols. Careful monitoring and further understanding of disease etiology and treatment strategies are needed.