Open AccessInflammation and endothelial activation are linked to renal function in long‐term kidney transplantation
Author(s) -
Cottone Santina,
Palermo Alessandro,
Vaccaro Francesco,
Mulè Giuseppe,
Guarneri Marco,
Arsena Rosalia,
Vadalà Anna,
Cerasola Giovanni
Publication year - 2007
Publication title -
transplant international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.998
H-Index - 82
eISSN - 1432-2277
pISSN - 0934-0874
DOI - 10.1111/j.1432-2277.2006.00405.x
Subject(s) - medicine , renal function , creatinine , transplantation , tumor necrosis factor alpha , kidney transplantation , kidney , inflammation , endothelial activation , vcam 1 , icam 1 , endocrinology , nephrology , cell adhesion molecule , kidney disease , gastroenterology , urology , immunology
Summary The aim of this study was to investigate the relationships between inflammation and adhesion molecules in long‐term kidney transplantation. We measured serum concentrations of tumor necrosis factor‐alpha (TNF α ) and intercellular and vascular cell adhesion molecules (ICAM‐1 and VCAM‐1) in 35 renal transplant recipients (mean age of transplantation 5 ± 3 years) and in 35 chronic renal insufficiency (CRI) patients; twenty‐six healthy subjects were enrolled as controls. Transplanted showed higher values than controls of TNF α ( P < 0.0001), ICAM‐1 ( P < 0.0001), and VCAM‐1 ( P < 0.0001). CRI group as well exhibited higher concentrations than controls of TNF α ( P < 0.0001), ICAM‐1 ( P < 0.0001), and VCAM‐1 ( P < 0.0001). Transplanted and CRI patients had similar blood pressure and renal function levels, and TNF α , ICAM‐1, and VCAM‐1 were not significantly different in the two groups. In transplanted group ICAM‐1, VCAM‐1, and TNF α correlated negatively and independently with glomerular filtration rate (GFR) – P < 0.00001 for all. TNF α as well correlated with ICAM‐1 and VCAM‐1 ( P < 0.001, respectively). In CRI group, TNF α correlated with serum creatinine, ICAM‐1, and VCAM‐1 ( P = 0.01 for all). In conclusion, in long‐term renal transplantation, the level of kidney function and both inflammation and endothelial activation are closely related. In fact, the multiple regression analysis demonstrated that the level of kidney insufficiency and the levels of the studied molecules were independently associated.