Open AccessChanges in endothelial function before and after renal transplantation*
Author(s) -
Oflaz Huseyin,
Turkmen Aydin,
Turgut Faruk,
Pamukcu Burak,
Umman Sabahattin,
Ucar Adem,
Akyol Yakup,
Uzun Sami,
Kazancioglu Rumeyza,
Kurt Ramazan,
Sever Mehmet S.
Publication year - 2006
Publication title -
transplant international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.998
H-Index - 82
eISSN - 1432-2277
pISSN - 0934-0874
DOI - 10.1111/j.1432-2277.2006.00288.x
Subject(s) - medicine , endothelial dysfunction , transplantation , reactive hyperemia , hemodialysis , endothelium , kidney disease , cardiology , renal function , kidney transplantation , brachial artery , nephrology , dialysis , urology , vasodilation , blood pressure
Summary Endothelial dysfunction is an early key event in the development of atherosclerotic cardiovascular disease observed in chronic renal failure patients. The role of renal transplantation (RTx) on endothelial dysfunction is still unclear. The aim of this study was to evaluate the endothelial function of chronic renal failure patients before RTx (while they were on hemodialysis, HD), and after RTx (at the 6th and 12th months) by a noninvasive method, brachial arterial ultrasound. A total of 22 (17 male, mean age: 33.9 ± 11.6 years) RTx recipients were enrolled in the study. Endothelium‐dependent vasodilation (EDD) was assessed by establishing reactive hyperemia. EDD prior to transplantation was significantly lower when compared with EDD measured at the 6th and 12th months after RTx (EDD pretransplantation: 6 ± 3.7%, EDD at the 6th month of RTx: 8.3 ± 2.3% and EDD at the 12th month of RTx: 12.1 ± 3.6%, P < 0.001). When the EDD values measured at the 6th and 12th months of RTx were compared, measurements of the 12th month were found significantly higher than those of the 6th month ( P < 0.001). Our results also showed that RTx has provided improvement in endothelial function by eliminating the uremic environment although not in the early post‐RTx period.