Open AccessThe prevention of infection post‐transplant: the role of prophylaxis, preemptive and empiric therapy
Author(s) -
Marty Francisco M.,
Rubin Robert H.
Publication year - 2006
Publication title -
transplant international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.998
H-Index - 82
eISSN - 1432-2277
pISSN - 0934-0874
DOI - 10.1111/j.1432-2277.2005.00218.x
Subject(s) - medicine , intensive care medicine , antimicrobial , hematopoietic stem cell , hematopoietic stem cell transplantation , graft versus host disease , population , empiric therapy , disease , immunology , hematopoietic cell , stem cell , haematopoiesis , pathology , alternative medicine , chemistry , organic chemistry , environmental health , biology , genetics
Summary The close linkage of infection with the nature and intensity of the transplant immunosuppressive program has led to the concept of the therapeutic prescription. This has two components: an immunosuppressive one to prevent or treat rejection and graft‐versus‐host disease and an antimicrobial one to make it safe. This review provides a conceptual framework to approach the risk and risk periods for infection in solid organ and hematopoietic stem cell transplant recipients as well as an approach to antimicrobial use in this population.