Open AccessEffect of different immunosuppressive therapies on the lipid pattern in kidney‐transplanted rats
Author(s) -
Lausada Natalia,
De Gómez Dumm Nelva T.,
Georgina Luna,
Gisela Camihort,
Clemente Raimondi
Publication year - 2005
Publication title -
transplant international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.998
H-Index - 82
eISSN - 1432-2277
pISSN - 0934-0874
DOI - 10.1111/j.1432-2277.2005.00084.x
Subject(s) - triglyceride , medicine , arachidonic acid , endocrinology , kidney , cholesterol , linoleic acid , pharmacology , fatty acid , chemistry , biochemistry , enzyme
Summary We analyzed the effect of oral administration of cyclosporine–methylprednisone (CsA–MP) and sirolimus (SRL) on the lipid pattern of kidney‐transplanted rats after a 7‐day survival. A significant increase in plasma cholesterol in CsA–MP group (control: 26 ± 3 mg/dl vs. 59 ± 8 mg/dl, P < 0.05) and in triglyceride levels in SRL group (control: 53 ± 4 mg/dl vs. 114 ± 3 mg/dl, P < 0.05), was shown. Kidney microsomal membranes from both treated groups showed that cholesterol and triglyceride values and the relative percentage of arachidonic acid in the total amount of n‐6 fatty acids decreased. A diminution of linoleic acid occurred in testis (control: 9.4 ± 0.1 mg/dl vs. CsA–MP: 6.0 ± 0.3 mg/dl and vs. SRL: 6.8 ± 0.2 mg/dl, P < 0.05), liver (control: 17.7 ± 0.6 mg/dl vs. CsA–MP: 15.1 ± 0.6 mg/dl and SRL: 13.5 ± 0.8 mg/dl, P < 0.05) and erythrocyte membranes (control:11.7 ± 0.1% vs. CsA‐MP: 10.6 ± 0.2% and SRL: 10.0 ± 0.4%, P < 0.01). The immunosuppressive therapies improved the rejection rate of the graft, fact that was remarkable in the SRL‐treated group. However, lipid abnormalities still remain in spite of immunosuppressive therapies. (150).