Open AccessInvolvement of tumor necrosis factor‐α receptor 1 and tumor necrosis factor‐related apoptosis‐inducing ligand‐(TRAIL) receptor‐2/ DR‐5, but not Fas, in graft injury in live‐donor liver transplantation
Author(s) -
Tashiro Hirotaka,
Itamoto Toshiyuki,
Ohdan Hideki,
Arihiro Kouji,
Tateaki Yuko,
Nakahara Hideki,
Ochi Makoto,
Hino Hiroshi,
Mizunuma Kazuyuki,
Hara Hidetaka,
Tokita Daisuke,
Onoe Takashi,
Ishiyama Kouhei,
Mitsuta Hiroshi,
Sugino Keizou,
Asahara Toshimasa
Publication year - 2004
Publication title -
transplant international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.998
H-Index - 82
eISSN - 1432-2277
pISSN - 0934-0874
DOI - 10.1111/j.1432-2277.2004.tb00397.x
Subject(s) - medicine , tumor necrosis factor alpha , fas ligand , liver transplantation , necrosis , liver injury , apoptosis , transplantation , pathology , receptor , programmed cell death , immunology , biology , biochemistry
The pathway leading to cell death in clinical liver transplantation is not known. Eight liver transplant recipients and eight donors were enrolled in this study. Postoperative serum levels of alanine transferase had significantly increased in the recipients compared with those in the donors. Mild centri‐lobular necrosis was observed in only liver tissues taken from the recipients. Tumor necrosis factor (TNF)‐R1 and death receptor 5 expression levels had increased in liver tissues taken from the recipients. There were no changes in the levels of Fas/Fas ligand expression in liver tissues from either the donors or recipients. Tumor necrosis factor‐related apoptosis‐inducing ligand (TRAIL) expression was down‐regulated in donor liver after hepatectomy and liver allograft after implantation. The results suggest that, although ischemic liver injury was not serious, due to the short ischemia time, TNF and TRAIL signals are associated with liver ischemic injury in live‐donor liver transplantation but Fas signal is not.