Open AccessEmbryonal rhabdomyosarcoma of the orbit in a liver transplant recipient
Author(s) -
Cescon Matteo,
Grazi Gian Luca,
Assietti Roberto,
Scanni Alberto,
Frigerio Franco,
Sparacio Francesca,
Ercolani Giorgio,
Cavallari Antonino,
Cescon M.,
Grazi G.L.,
Ercolani G.,
Cavallari A.
Publication year - 2003
Publication title -
transplant international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.998
H-Index - 82
eISSN - 1432-2277
pISSN - 0934-0874
DOI - 10.1111/j.1432-2277.2003.tb00327.x
Subject(s) - medicine , immunosuppression , embryonal rhabdomyosarcoma , rhabdomyosarcoma , surgery , liver transplantation , chemotherapy , diplopia , radiation therapy , fulminant hepatic failure , transplantation , sarcoma , pathology
Although an increased incidence of de novo malignancies is reported in transplant recipients, rhabdomyosarcoma, an aggressive mesenchymal tumor typical of childhood, is not considered a neoplasm commonly related to immunosuppression. A 21‐year‐old woman presented with unilateral diplopia and proptosis 16 months after liver transplantation for fulminant hepatic failure. A tumoral mass originating from the medial rectus muscle was partially removed and diagnosed as being an embryonal rhabdomyosarcoma. Since the patient refused complete orbital excision, one course of radiotherapy and six courses of chemotherapy were administered, while immunosuppression was re‐modulated, without interruption of the administration of cyclosporine. Complete control of tumor growth was achieved, while no alterations of graft function were observed throughout the treatment period.