Open AccessIncidence of minor and major amputations after pancreas/kidney transplantation
Author(s) -
Woeste Guido,
Wullstein Christoph,
Pridöhl Olaf,
Lübke Peter,
Schwarz Rene,
Kohlhaw Kay,
Bechstein Wolf O.
Publication year - 2003
Publication title -
transplant international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.998
H-Index - 82
eISSN - 1432-2277
pISSN - 0934-0874
DOI - 10.1111/j.1432-2277.2003.tb00274.x
Subject(s) - medicine , dialysis , amputation , transplantation , diabetes mellitus , incidence (geometry) , surgery , kidney transplantation , pancreas transplantation , kidney disease , retrospective cohort study , physics , optics , endocrinology
Among other complications, diabetes mellitus leads to peripheral vascular disease with the risk of limb amputation. This retrospective study analyzed the incidence of amputations after simultaneous pancreas‐kidney transplantation (SPK). Between June 1994 and February 2001, 200 SPKs, nine pancreas‐after‐kidney‐(PAK) and one pancreas transplantation alone (PTA) were performed. The overall 5‐year patient, pancreas‐, and kidney‐graft survival rates were 92.4%, 80.2% and 85.6%, respectively. Mean age at transplantation was 38.7 years, mean duration of diabetes was 26.9 years, mean duration of dialysis was 26.7 months. Nineteen (9.5%) patients after SPK (seven female/12 male) underwent 33 amputations, on average 18.7 months after transplantation. Longer duration of dialysis and a previous history of amputation were significant risk factors for an amputation after SPK ( P =0.014, P <0.001). Thus, early referral for SPK before dialysis initiation may be beneficial in preventing amputation.