Open AccessHepatocyte growth factor and transforming growth factor β1 contribute to regeneration of small‐for‐size liver graft immediately after transplantation
Author(s) -
Ninomiya Mizuki,
Harada Noboru,
Shiotani Satoko,
Hiroshige Shoji,
Minagawa Ryosuke,
Soejima Yuji,
Suehiro Taketoshi,
Nishizaki Taketoshi,
Shimada Mitsuo,
Sugimachi Keizo
Publication year - 2003
Publication title -
transplant international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.998
H-Index - 82
eISSN - 1432-2277
pISSN - 0934-0874
DOI - 10.1111/j.1432-2277.2003.tb00246.x
Subject(s) - hepatocyte growth factor , liver regeneration , transforming growth factor , hepatocyte , medicine , regeneration (biology) , liver transplantation , transplantation , growth factor , endocrinology , andrology , biology , microbiology and biotechnology , receptor , biochemistry , in vitro
Although the ability of the liver to regenerate to a predetermined size after resection made adult‐to‐adult living donor liver transplantation (LDLT) possible, there is little information regarding the growth regulatory mechanism for a small‐for‐size graft. Forty‐one cases of LDLT were divided into two groups by graft volume to standard liver volume ratio (GV/SLV); small graft group (Group S, GV/SLV>40%, n =16) and nonsmall graft group (Group NS, GV/SLV>40%, n =25). The regeneration rate (GV at 1 week/harvested GV) and serum levels of hepatocyte growth factor (HGF), transforming growth factor‐α (TGF‐α) and transforming growth factor‐β1 (TGF‐β1) were compared between two grous. The regeneration rates in Group S were significantly higher than that of Group NS (217, 12% and 178, 10%, respectively, P >0.01). The serum HGF levels of Group S were significalty higher than hjose of Group NS on POD 1. The TGF‐β1 levels of Group S were significatly higher than those of Group NS on POD 3 and 5. The TGF‐α levels were not different at any time points studied. These results indicate that a small‐for‐size graft retains the capacity to regenerate faster by modulation of expression pattern of HGF and TGF‐β1 immediately after LDLT. After the acceleration of the regenerative response by HGF, subsequent elevation of TGF‐β1 synergisically controls graft size, regulating uncontrolled proliferation of hepatocytes.