Open AccessOutcome of orthotopic liver transplantation in autoimmune hepatitis according to subtypes
Author(s) -
Cattan Pierre,
Berney Thierry,
Conti Filomena,
Calmus Yvon,
Homberg J.C.,
Houssin Didier,
Soubrane Olivier
Publication year - 2002
Publication title -
transplant international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.998
H-Index - 82
eISSN - 1432-2277
pISSN - 0934-0874
DOI - 10.1111/j.1432-2277.2002.tb00095.x
Subject(s) - medicine , autoimmune hepatitis , liver transplantation , orthotopic liver transplantation , hepatology , hepatitis , gastroenterology , transplantation , immunology
The relevance of autoimmune hepatitis (AIH) classification for clinical purposes is controversial. We analyzed the outcome after orthotopic liver transplantation (OLT) of nine type I and seven type II AIH patients. Type II patients had a significantly higher incidence of cirrhosis at the time of diagnosis, more resistance to steroid therapy, and a higher Child‐Pugh score at the time of OLT. OLT was performed in emergency in three type II patients and electively in all type I patients. Four type II and one type I patients died in the postoperative period. There was no difference regarding the incidence of post‐OLT infection and rejection between the two types. The 6‐year actuarial survival rates for type I and type II patients were 76% and 43%, respectively. Type II AIH patients who have a poor response to medical therapy should be considered for OLT with a shortened delay.