Open AccessBronchiolitis obliterans organizing pneumonia (BOOP) with suspected liver graft‐versus‐host disease after allogeneic bone marrow transplantation
Author(s) -
Kanamori H.,
Mishima A.,
Tanaka H.,
Yamaji S.,
Fujisawa S.,
Koharazawa H.,
Nishikawa M.,
Mohri H.,
Ishigatsubo Y.,
Matsuzaki M.
Publication year - 2001
Publication title -
transplant international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.998
H-Index - 82
eISSN - 1432-2277
pISSN - 0934-0874
DOI - 10.1111/j.1432-2277.2001.tb00056.x
Subject(s) - medicine , bronchiolitis obliterans organizing pneumonia , bronchiolitis obliterans , bronchoalveolar lavage , chronic myelogenous leukemia , prednisolone , pneumonia , respiratory disease , bone marrow , pathology , lung , gastroenterology , lung transplantation , leukemia
We report on a patient with chronic myelogenous leukemia who developed bronchiolitis obliterans organizing pneumonia (BOOP) after allogeneic bone marrow transplantation (BMT). A 19‐year‐old Japanese male complained of dry cough and dyspnea 7 months after BMT. The chest X‐ray and computed tomography revealed patchy infiltrates bilaterally. Lung function test, lung biopsy and bronchoalveolar lavage were consistent with the diagnosis of BOOP. The patient also suffered from suspected graft‐versus‐host disease (GVHD) of the liver, after discontinuation of cyclosporine. Furthermore, prednisolone proved effective against the BOOP and the liver dysfunction. These findings indicate that BOOP is a possible pulmonary manifestation of chronic GVHD, and that immunological mechanisms may have effected the onset of BOOP after BMT in this case.