Open AccessWithdrawal of cyclosporine in renal transplant recipients with acute tubular necrosis improves renal function
Author(s) -
Kahn D.,
Botha J.F.,
Pascoe M.D.,
Pontin A.R.,
Halkett J.,
Tandon V.
Publication year - 2000
Publication title -
transplant international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.998
H-Index - 82
eISSN - 1432-2277
pISSN - 0934-0874
DOI - 10.1111/j.1432-2277.2000.tb02123.x
Subject(s) - medicine , acute tubular necrosis , anti thymocyte globulin , renal function , creatinine , urology , immunosuppression , transplantation , kidney , kidney transplantation , nephrotoxicity , nephrology , incidence (geometry) , gastroenterology , surgery , physics , optics
In this study, patients with acute tubular necrosis (ATN) after renal transplantation were prospectively randomized to either conventional immunosuppression or withdrawal of cyclosporine and replacement with anti‐thymocyte globulin (ATG). The patients treated with cyclosporine withdrawal and ATG had a significantly shorter duration of ATN (8.9 ± 1.5 vs 10.8 ± 1.4 days; P < 0.05) and better renal function (mean serum creatinine on day 5 postoperatively: 740 ± 49 vs 918 ± 73 μmol/l; P < 0.05). The incidence of acute rejection was lower in the patients with cyclosporine withdrawal and ATG. In conclusion, cyclosporine is toxic to the renal allograft with ATN, and withdrawal of cyclosporine shortens the duration of ATN and improves renal function.