Open AccessOgilvie's syndrome associated with acute cytomegaloviral infection after liver transplantation
Author(s) -
Shapiro A. M. James,
Bain Vincent G.,
Preiksaitis Jutta K.,
Ma Mang M.,
Issa Samir,
Kneteman Norman M.
Publication year - 2000
Publication title -
transplant international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.998
H-Index - 82
eISSN - 1432-2277
pISSN - 0934-0874
DOI - 10.1111/j.1432-2277.2000.tb01034.x
Subject(s) - medicine , liver transplantation , colonic pseudo obstruction , ganciclovir , cytomegalovirus , complication , pathogenesis , gastroenterology , cytomegalovirus infection , transplantation , immunology , human cytomegalovirus , herpesviridae , viral disease , human immunodeficiency virus (hiv) , virus
Ogilvie's syndrome, or acute colonic pseudo‐obstruction, is a rare complication following liver transplantation. We describe two cases in which the onset of Ogilvie's syndrome is strongly temporally associated with acute cytomegaloviral (CMV) infection in immunosuppressed liver transplant recipients. The pseudo‐obstruction resolved rapidly in both cases following treatment with intravenous ganciclovir. Acute CMV infection therefore appeared to be causally linked to pathogenesis of Ogilvie's syndrome in these two cases. This association has not been described previously to our knowledge, and should be considered in any transplant patient presenting with Ogilvie's syndrome.