Open AccessLong‐term follow up of renal function and histology after renal allograft transplantation in early childhood
Author(s) -
Qvist E.,
Krogerus L.,
Laine J.,
Jalanko H.,
Rönnholm K.,
Salmela K.,
Sairanen H.,
Leijala M.,
Holmberg C.
Publication year - 1998
Publication title -
transplant international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.998
H-Index - 82
eISSN - 1432-2277
pISSN - 0934-0874
DOI - 10.1111/j.1432-2277.1998.tb01163.x
Subject(s) - medicine , transplantation , immunosuppression , renal function , kidney transplantation , urology , surgery , nephrology , kidney , pathological
Survival rates, renal function, and histopathology were evaluated in 49 prospectively followed patients transplanted under 5 years of age at our center. Most patients (84%) suffered from congenital nephrosis of the Finnish type. Triple immunosuppression with cyclosporin administered in three daily doses to pre‐school children was used. Patient survival 7 years after transplantation was 98 % and graft survival 88 %. All graft losses were due to post‐transplantation nephrosis. The proportion of pathological findings in the follow‐up biopsies did not change substantially with time. Five years after transplantation, 47 % showed a normal histology and after 7 years this rose to 67 %. Mean glomerular filtration rate (GFR) was 68 and 55 ml min per 1.73 m 2 5 years and 7 years, respectively, after transplantation. The decline in GFR with time was significant. We conclude that good long‐term results can be achieved with individually tailored triple immunosuppression in the youngest age group, even with cadaveric donors.