Open AccessFactors relevant for the induction of rejection by indirect recognition in a rat heart allograft model: effect of CTLA4lg treatment on indirect alloactivation induced by immunization with donor MHC I peptides
Author(s) -
Dufter C.,
Watzlik A.,
Opelz G.,
Terness P.
Publication year - 1998
Publication title -
transplant international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.998
H-Index - 82
eISSN - 1432-2277
pISSN - 0934-0874
DOI - 10.1111/j.1432-2277.1998.tb01156.x
Subject(s) - allorecognition , medicine , major histocompatibility complex , immunology , heart transplantation , immune system , immunization , transplantation
We have defined factors relevant for the induction of rejection by indirect recognition in a rat heart allograft model and analyzed the influence of CTLA4Ig treatment on indirect alloactivation induced by donor MHC I peptides in a DA → LEW heart allograft model. Indirect allorecognition of MHC I led to accelerated graft rejection and was accompanied by the induction of anti‐peptide antibodies and donor pep‐tide‐activated T cells. In an attempt to block the B7‐induced costimulatory signal of T cell activation, CTLA4Ig was administered to graft recipients in addition to MHC I peptide treatment. CTLA4Ig therapy, however, was not effective in preventing the humoral or cellular anti‐donor immune response, nor did it prevent accelerated graft rejection.