Open AccessTacrolimus rescue therapy for cyclosporine‐induced nephrotoxicity
Author(s) -
HernándezHerrera G.,
Castillo D. Del,
Pérez R.,
LópezRubio F.,
Aljama P.
Publication year - 1998
Publication title -
transplant international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.998
H-Index - 82
eISSN - 1432-2277
pISSN - 0934-0874
DOI - 10.1111/j.1432-2277.1998.tb01090.x
Subject(s) - medicine , nephrotoxicity , tacrolimus , rescue therapy , renal function , nephrology , hemodialysis , transplantation , urology , salvage therapy , surgery , intensive care medicine , kidney , chemotherapy
Following renal transplantation, the long‐term use of cyclosporine can cause nephrotoxicity. This small study of ten patients looks at the effects of tacrolismus rescue therapy over a 6‐month period. After conversion to tacrolismus, renal function improved in seven pateints, progressive graft dysfunction slowed and almost stabilized in two patients, and, in the remaining patient, deterioration continued and hemodialysis treatment was initiated at the end of the study period. A greater number of patients and a longer follow up are necessary to confirm these initially impressive results.