Open AccessFocal segmental glomerulosclerosis in a kidney transplant population: hereditary and sporadic forms
Author(s) -
Felldin Marie,
Nordén Gunnela,
Svalander Christian,
Nyberg Gudrun
Publication year - 1998
Publication title -
transplant international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.998
H-Index - 82
eISSN - 1432-2277
pISSN - 0934-0874
DOI - 10.1111/j.1432-2277.1998.tb00950.x
Subject(s) - medicine , focal segmental glomerulosclerosis , transplantation , kidney transplantation , nephrology , population , surgery , kidney , gastroenterology , glomerulonephritis , environmental health
Abstract Between 1985 and 1993, 16 of 1000 kidney transplant patients in Göteborg had biopsy‐verified primary focal segmental glomerulosclerosis (FSGS), and among them they received 23 transplants. Their age range was 19–67 years (median 39 years). Patients were followed for 3–10 years (median 6.5 years). Eight patients were members of seven separate families in which at least one other member had FSGS, while eight cases were sporadic. The patients with hereditary FSGS were younger at onset of symptoms than sporadic cases (median 12.5 vs 26 years, P = 0.041) but not at the time of renal failure. Only one versus five had received immunotherapy. After transplantation, recurrence of FSGS occurred in five grafts, all in sporadic cases, and two of these were lost. In conclusion, it appears that there are at least two forms of FSGS, one hereditary and one sporadic form. The hereditary form does not seem to recur after transplantation, whereas the risk in sporadic cases is very high.