Open AccessDevelopmentally regulated expression of linker‐histone variants in vertebrates
Author(s) -
Khochbin Saadi,
Wolffe Alan P.
Publication year - 1994
Publication title -
european journal of biochemistry
Language(s) - English
Resource type - Journals
eISSN - 1432-1033
pISSN - 0014-2956
DOI - 10.1111/j.1432-1033.1994.00501.x
Subject(s) - histone , linker , biology , chromatin , histone h1 , genetics , function (biology) , computational biology , microbiology and biotechnology , gene , computer science , operating system
The identification of histone H1 variants in vertebrates suggests that these proteins may have specialized functions. During embryonic development, a correspondence between the expression of each of the linker‐histone variants and the proliferative and transcriptional activity of embryonic cells can be observed. Analysis of the developmentally regulated expression of these variants leads to the subdivision of these variants into distinct classes. This subdivision may also provide insight into the significance of the differential expression of variants and the roles individual linker histones have in chromatin structure and function.