Open AccessSmall RNA helices as substrates for aminoacylation and their relationship to charging of transfer RNAs
Author(s) -
FRANCKLYN Christopher,
MUSIERFORSYTH Karin,
SCHIMMEL Paul
Publication year - 1992
Publication title -
european journal of biochemistry
Language(s) - English
Resource type - Journals
eISSN - 1432-1033
pISSN - 0014-2956
DOI - 10.1111/j.1432-1033.1992.tb16929.x
Subject(s) - aminoacylation , transfer rna , genetic code , rna , sequence (biology) , biology , nucleotide , amino acid , computational biology , chemistry , genetics , gene
RNA microhelices that reconstruct the acceptor stems of transfer RNAs can be aminoacylated. The anticodon‐independent aminoacylation is sequence‐specific and suggests a relationship between amino acids and nucleotide sequences which is different from that of the classical genetic code. The specific aminoacylation of RNA microhelices also suggests a highly differentiated adaptation of the structures of aminoacyl‐tRNA synthetases to sequences in the acceptor stems of transfer RNAs.