Open AccessMetabolic control analysis
Author(s) -
FELL David A.,
SAURO Herbert M.
Publication year - 1990
Publication title -
european journal of biochemistry
Language(s) - English
Resource type - Journals
eISSN - 1432-1033
pISSN - 0014-2956
DOI - 10.1111/j.1432-1033.1990.tb19212.x
Subject(s) - substrate (aquarium) , control (management) , moiety , metabolic control analysis , enzyme , flux (metallurgy) , mathematics , metabolic pathway , chemistry , control theory (sociology) , biological system , computer science , stereochemistry , biochemistry , biology , ecology , microbiology and biotechnology , organic chemistry , artificial intelligence , insulin
Differing views have been given in the literature as to whether the presence in a pathway of an enzyme at a concentration comparable to that of its substrate affects the values of control coefficients and the theorems of metabolic control analysis. Here we argue in favour of one of those views: that there is no effect unless the enzyme sequesters a substrate that contains a conserved moiety. In this particular case, we derive both a general criterion for estimating whether such an effect will be of a significant magnitude, and equations for determining the changes in the flux control coefficients. The nature of the phenomenom and the application of the equations are illustrated with a numerical simulation.