Open AccessConformation of two somatostatin analogues in aqueous solution
Author(s) -
WYNANTS Chantal,
TOURWE Dirk,
KAZMIERSKI Wieslaw,
HRUBY Victor J.,
BINST Georges
Publication year - 1989
Publication title -
european journal of biochemistry
Language(s) - English
Resource type - Journals
eISSN - 1432-1033
pISSN - 0014-2956
DOI - 10.1111/j.1432-1033.1989.tb15125.x
Subject(s) - circular dichroism , aqueous solution , disulfide bond , chemistry , somatostatin , nuclear magnetic resonance spectroscopy , stereochemistry , crystallography , organic chemistry , biochemistry , neuroscience , biology
Cyclic‐disulfide‐containing analogues of somatostatin, [Xaa 1 = H or DPhe; Xaa 3 = Phe or Tyr; Xaa 7 = Cys, Me 2 Cys or Me 2 DCys; Xaa 8 = OH, Thr 8 (OH) or Thr 8 NH 2 ], were examined in aqueous solution by 1 H‐NMR spectroscopy and circular dichroism. The influence of the helical nature of the disulfide bridge and the presence of exocyclic residues on biological activity were investigated with particular care.