Solution conformation of sialosylcerebroside (G M4 ) and its NeuAc(α2→3)Galβ sugar component | Zendy

POPPE Leszek | Zendy; DABROWSKI Janusz | Zendy; LIETH ClausWilhelm | Zendy; NUMATA Masaaki | Zendy; OGAWA Tomoya | Zendy

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Solution conformation of sialosylcerebroside (G M4 ) and its NeuAc(α2→3)Galβ sugar component

Author(s) -

POPPE Leszek,

DABROWSKI Janusz,

LIETH ClausWilhelm,

NUMATA Masaaki,

OGAWA Tomoya

Publication year - 1989

Publication title -

european journal of biochemistry

Language(s) - English

Resource type - Journals

eISSN - 1432-1033

pISSN - 0014-2956

DOI - 10.1111/j.1432-1033.1989.tb14653.x

Subject(s) - disaccharide , conformational isomerism , chemistry , ganglioside , sugar , nuclear magnetic resonance spectroscopy , carbohydrate conformation , stereochemistry , crystallography , organic chemistry , molecule , biochemistry

The solution conformations of G M4 ganglioside [NeuAc(α2→3)Gal(β→1)Cer] in ( 2 H 3 C) 2 SO and its component disaccharide in 2 H 2 O were investigated with the aid of 1 H‐nuclear magnetic resonance spectroscopy (nuclear Overhauser effect, analysis of coupling constants) and by energy‐minimum calculations. The existence of three low‐energy conformers obtained by theoretical calculations was supported by experimental findings in the case of G M4 , whereas the disaccharide appears to exist as a mixture of two conformers.

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