Open AccessControl of mitochondrial transcription by thyroid hormone
Author(s) -
MUTVEI Ann,
KUZELA Stefan,
NELSON B. Dean
Publication year - 1989
Publication title -
european journal of biochemistry
Language(s) - English
Resource type - Journals
eISSN - 1432-1033
pISSN - 0014-2956
DOI - 10.1111/j.1432-1033.1989.tb14638.x
Subject(s) - mitochondrial dna , hormone , thyroid , transcription (linguistics) , mitochondrion , biology , thyroid hormone receptor , thyroid hormone receptor beta , medicine , endocrinology , microbiology and biotechnology , gene , hormone receptor , genetics , linguistics , philosophy , cancer , breast cancer
Thyroid hormone regulation of rat liver mitochondrial transcription was investigated. Steady‐state levels of mitochondrial transcripts were measured by Northern blot analysis using cloned fragments of rat mtDNA. Thyroid hormone increased the steady‐state concentrations of all mitochondrial mRNAs by 2–8 fold after 1–3 days of hormone treatment, whereas no significant change in the mitochondrial rRNA was observed. Analysis of transcript synthesis in isolated mitochondria shows that part or all of this increase is accounted for by elevated synthesis. Mechanisms by which thyroid hormone regulates transcription of the mitochondrial genome are discussed.