Open AccessCo‐operative and allosteric enzymes: 20 years on
Author(s) -
RICARD Jacques,
CORNISHBOWDEN Athel
Publication year - 1987
Publication title -
european journal of biochemistry
Language(s) - English
Resource type - Journals
eISSN - 1432-1033
pISSN - 0014-2956
DOI - 10.1111/j.1432-1033.1987.tb13510.x
Subject(s) - cornish , humanities , national laboratory , art , physics , philosophy , engineering physics , linguistics
The concepts of co-operativity and allosteric behaviour in proteins have been commonplace in biochemistry for about 20 years, since the classic papers of Monod, Wyman and Changeux [l] and Koshland, Nkmethy and Filmer [2]. Nonetheless, the two terms are not always clearly distinguished or used consistently, and in any case the definitions that were appropriate originally may not still be so today. So we should begin by defining what we mean by co-operative and allosteric behaviour.