Open AccessAnticholinesterase activity of a new carbamate, heptylphysostigmine, in view of its use in patients with Alzheimer‐type dementia
Author(s) -
BRUFANI Mario,
MARTA Maurizio,
POMPONI Massimo
Publication year - 1986
Publication title -
european journal of biochemistry
Language(s) - English
Resource type - Journals
eISSN - 1432-1033
pISSN - 0014-2956
DOI - 10.1111/j.1432-1033.1986.tb09646.x
Subject(s) - acetylcholinesterase , cholinesterase , carbamate , dementia , incubation , in vitro , chemistry , pharmacology , aché , enzyme , drug , biochemistry , medicine , disease
The anticholinesterase activity of a new carbamate, heptylphysostigmine, was studied in vitro . This compound is a competitive inhibitor of acetylcholinesterase (or true cholinesterase) having K i = (1 ± 0.5) × 10 −7 M. The inhibition was instantaneous at the onset and did not diminish with prolonged incubation of the drug and enzyme.