Open AccessReaction of cimetidine with Fenton reagent
Author(s) -
ZBAIDA Shmuel,
KARIV Rami,
FISCHER Paula,
SILMANGREENSPAN Judith,
TASHMA Zeev
Publication year - 1986
Publication title -
european journal of biochemistry
Language(s) - English
Resource type - Journals
eISSN - 1432-1033
pISSN - 0014-2956
DOI - 10.1111/j.1432-1033.1986.tb09441.x
Subject(s) - cimetidine , reagent , chemistry , sulfoxide , dimethyl sulfoxide , catalysis , chromatography , organic chemistry , pharmacology , medicine
Cimetidine sulfoxide, N ‐desmethylcimetidine, N ‐desmethylcimetidine sulfoxide, cimetidine guanylurea, and the 5‐hydroxymethylimidazole derivative of cimetidine sulfoxide were isolated from the reaction of cimetidine with Fenton reagent. The product distribution from the reaction of cimetidine with Fenton reagent clearly simulates the metabolism of cimetidine by the mixed‐function oxidase.